Investors focus on the Fed's policy decision and Chair Jerome Powell's news conference. Earnings from Meta and Microsoft are due after the closing bell.

The S&P 500 was edging up by 0.1% in early trading, coming off its first loss after setting all-time highs for six successive days. The Dow Jones Industrial Average was up 21 points, or less than 0.1%, as of 9:35 a.m. Eastern time, and the Nasdaq composite was adding 0.3%.

The S&P 500 closed lower Wednesday as the Federal Reserve left interest rates unchanged, even as two policymakers dissented—the first double dissent since 1993—highlighting growing divisions over the future of monetary policy.