A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural biologists at RIKEN. This could inform the development of new therapies.

By clarifying how the DNA sequence affects transcription accuracy, the study offers a new perspective on its fidelity, suggesting that errors are not in random locations but are instead influenced ...

What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time.

Animation of DNA’s knot-like i-motif structure the team mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene activity ...

Aging is accompanied by genetic changes — gene-expression shifts and pathways go haywire. Why this happens has been poorly understood. New findings provide an answer.

Transcription of a gene begins when RNAP binds to a 'promoter' DNA sequence and ends at a 'terminator' sequence where the mRNA copy is released.

Scientists studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.

In addition to BRCA1’s role in repairing DNA damage and preventing it from accumulating across the genome, the study indicates this invaluable protein appears to improve transcription fidelity.